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  1. I’ve been on Alprazolam [xanax] for 12-years now [34-yrs old currently]. I have severe Panic Disorder They don’t “fix” the problem and I’ve never expected them to. But when I’m having back to back to back panic attacks multiple times per day, there is no other substance or non-drug intervention that even comes close to helping ME, PERSONALLY as well as Xanax.

    Ive tried everything. Literally. To the point I was put on the drug Lexapro, for example, three times. SSRI / SNRI medications are some of the worst I’ve personally encountered during the initial “testing period”. This is when I was first seeing which medications, in conjunction w/ CBT, meditation, breathing exercises, normal talk therapy, etc. helped me specifically the best. Initially Klonopin [Clonazepam], which is also a Benzodiazepine, helped a lot. However, I quickly realized it wasn’t powerful enough. More importantly, it’s a much longer-acting drug [duration is usually close to 12hrs] whereas the duration of Xanax is between 4 and 6hrs. I didn’t need to be on benzodiazepines 24hrs /per-day. If I was able to get past a panic attack w/ a ‘first line” technique like removing myself from the situation, counting breaths, getting into a meditative state if possible, then I wouldn’t need to take a dose. So I ended up on a relatively high dose of Xanax [because of some odd inherent tolerance I had, prior to ever taking any benzodiazepines). It saved my life. Literally. Yes, I’m physically dependent on benzodiazepines, but I knew what I was getting into on a pharmacological level and the benefits far outweighed the risks.

    They’re not for everyone, specifically for long-term daily use as they’re prescribed to me. Everyone’s body is different and yes, pharmacologically one can usually expect a drug to exhibit a similar effect on most people. That, however, is not a monolith and is a concept medical professionals need to start getting away from. These drugs do show varied effects person-to-person. Sometimes insignificant — other times drastic. Another great example of this is Opioids — varied effects when observed in those taking the medication. This “pharmaceutical determinism”, where doctors expect a drug to do the exact same thing to everyone, all the time, needs to be [and has greatly been] proven false, from a factual standpoint. There are papers published on it. Every medication has its known characteristics, but on a patient-to-patient basis, the effects of medications can vary widely.

    Also, Ambien [zolpidem] and Xanax [alprazolam] are NOT in the same drug category at all. They’re both “sedatives” but are in completely different “families” or categories. Ambien is not a Benzodiazepine. Frankly, Ambien is one of the strangest molecules ever, in the minds of a lot of pharmacologically interested people. It’s very unique and is technically a sedative / hypnotic almost deliriant.

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